Exosomes seek out specific cellular targets and, upon arriving at their intended destination, can transfer their cargo of mRNA, miRNA, and growth factors to recipient cells or activate signaling pathways in order to change the behavior of the recipient cell.

  • Clinical trials are already underway designed to test the hypotheses that Exosomes might serve as a therapy to alter the inflammatory response.
  • Early findings suggest that MSC-derived exosomes can modulate the phenotype of macrophages. This is the likely Mechanism of Action that Exosomes exert on inflammation since macrophages play a pivotal role in regulating immune responses.
  • Macrophages assume both phagocytic “defensive” roles and exhibit regulatory “anti-inflammatory” actions, mediating both the initiation and resolution of inflammation.